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Immunology MCQs with Brief Explanatory Answers

Immunology MCQs with Brief Explanatory Answers

Immunology is defined as a branch of biology and medicine that covers the study of immune systems in all organisms. The term immunology was coined by Russian biologist Ilya Ilyich Mechnikov,[10] who advanced studies on immunology and received the Nobel Prize for his work in 1908. The important lymphoid organs of the immune system include thymus, bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. There are two types of Immune System in humans that is classified based on the resistance power against the infectious agents. These two types are namely the Innate Immune System & Adaptive Immune System. Given below are the top 10 multiple choice questions on immunology with brief explanatory answers and solutions.

Auto-immunity develops due to

Auto-immunity develops due to

  1. Loss of B cells
  2. Loss of T cells
  3. Loss of plasma cells
  4. Loss of complement
  5. Loss of immunological tolerance

Correct answer: 5. Loss of immunological tolerance

Nude mice have no

Nude mice have no

  1. B cells
  2. Thymic stroma
  3. Clothes
  4. Skin

Correct answer: 2. Thymic stroma

Injection of anti-venom to a patient for snake bite is an example of

Injection of anti-venom to a patient for snake bite is an example of

  1. Artificially acquired active immunity
  2. Artificially acquired passive immunity
  3. Naturally acquired active immunity
  4. Naturally acquired passive immunity

Correct answer: 2. Artificially acquired passive immunity

Explanation: Passive immunity is “borrowed” from another source and it lasts for a short time. Antivenom is a biological product that is used to treat the snake bites of venom snakes, It comprises of antibodies.

Double positive T cells express

Double positive T cells express

  1. Both ab and gd tcr
  2. Both cd3 and cd4
  3. Both cd3 and cd8
  4. Both cd4 and cd8

Correct answer: 4. Both cd4 and cd8

Explanation: Double positive” T cell refers to CD4 and CD8 co-receptor expression

All of below are characteristic symptoms of inflammation except

All of below are characteristic symptoms of inflammation except:

  1. Redness
  2. Cyanosis
  3. Swelling
  4. Pain
  5. Heat

Correct answer: 2. Cyanosis

Newborns getting their antibodies from mother’s milk is an example of

Newborns getting their antibodies from mother’s milk is an example of

  1. Artificially acquired active immunity
  2. Artificially acquired passive immunity
  3. Naturally acquired active immunity
  4. Naturally acquired passive immunity

Correct answer: 4. Naturally acquired passive immunity

Explanation: Passive immunity is “borrowed” from another source and it lasts for a short time. Newborns getting their antibodies from mothers milk is an example of naturally acquired passive immunity.

Naturally acquired active immunity would be most likely acquired through

Naturally acquired active immunity would be most likely acquired through:

  1. Vaccination
  2. Drinking colostrum
  3. Natural birth
  4. Infection with disease-causing organism followed by recovery
  5. Both 2 & 3

Correct answer: 4. Infection with disease-causing organism followed by recovery

The capability of the immune system to recognize self-antigens versus nonself antigen is an example of which of following

The capability of the immune system to recognize self-antigens versus nonself antigen is an example of which of following:

  1. Antigenic immunity
  2. Cell-mediated immunity
  3. Specific immunity
  4. Tolerance

Correct answer: 4. Tolerance

Which of following is not involved in first line defense

_________  is not involved in first line defense

  1. Mucus membranes
  2. Saliva
  3. Tears
  4. Antibodies      

Correct answer: 4. Antibodies

T cells differ from B cells by expressing

T cells differ from B cells by expressing which of the following

  1. Antigen receptor of only one isotype
  2. Antigen receptor of only one idiotype
  3. Crag-1 and rag-2 during somatic recombination.
  4. A surrogate chain before somatic recombination of the second receptor chain is complete
  5. Signal transduction molecules with their antigen receptor

Correct answer: 1. antigen receptor of only one isotype

Explanation: Mature B cells have both IgM and IgD BCR, while mature T cells have (usually) alpha/beta or (sometimes) gamma/delta TCR.

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